Cera Products Inc.
The development of Cera Product’s oral rehydration therapy (ORT) products
began in Bangladesh at the International Center for Diarrheal Disease
Research in Dhaka (ICDDRB) during the 1980s. It was at the ICDDRB where Cera
Products Inc. president, Charlene Riikonen, Dr. David Sack and Dr. W. B.
Greenough III met and worked together with the intention of preventing
unnecessary suffering, severe illnesses and death by assisting individuals
who were afflicted with dehydration and diarrhea. After returning to the
United States, attempts were made to find a pharmaceutical company to take
on the burden of developing a faster, more effective and better tolerated
form of oral rehydration therapy. At the time no large pharmaceutical
companies were interested in the research and development of a rice-based
ORS product. Determined to develop a rice-based oral rehydration therapy
product; Cera Products was founded in 1993 by Charlene Riikonen and Esko
Riikonen. From there work began to find appropriate manufacturing partners
in the United States and to develop the formulations.
In 1996, as part of an ongoing clinical research and product development
relationship with Johns Hopkins University physicians Dr. Greenough and Dr.
Sack, Cera Products Inc. undertook clinical studies. Following the initial
results Cera Products, Inc. applied for its patents and began to manufacture
CeraLyte ORS. In 1997, the core technology and formulations that comprise
Cera’s products were awarded a U.S. patent. Since its first patent, Cera
Products has continued to grow so that now the Company manufactures five
specific oral hydration delivery products: CeraLyte®, CeraSport®, CeraFlu™,
CeraVacx®, and CeraVet®. Cera’s products are kosher OU certified, and
manufactured in the United States under GMP and with the formulations
specified by the World Health Organization for ORS. A second patent for
global applications is pending. CeraLyte® is a rice-based oral electrolyte or “ORS” that prevents and
corrects dehydration from diarrhea. Because of its unique patented
formulation of mixed chain rice carbohydrate at low osmolarity of <220 mOsm/Liter,
CeraLyte reduces diarrhea as it hydrates.
Current distribution is USA, including hospitals, nursing homes and the
US government. Distribution also is in South Africa, Canada, Central
America, Korea, and other countries in process in Asia and Europe, as
well as to Pakistan, El Salvador, Haiti, Myanmar, parts of Africa, and
other disaster-stricken areas via charitable giving from Cera Products
to Child Health Foundation (CHF), Direct Relief International (DRI) and
other charities. Research:
Research on Low Osmolarity and Rice-Based ORS
The challenge of increased diarrhea output due to the presence of too
much glucose has been researched by examining rice-based verses
glucose-based oral rehydration solutions. The glucose molecules in a
rice-based solution are in the form of a complex carbohydrate. Complex
carbohydrate chains of glucose have a low osmolarity, which helps to
avoid the negative side of effects of too much glucose. As a result,
research has shown that rice-based carbohydrate solutions have a
significant advantage over standard glucose-based solutions, by
accelerating the adsorption of fluids and electrolytes while reducing diarrhea. References:
1. Duggan C, Fontaine O, Pierce NF, et al (2004). “Scientific Rationale
for a Change in the Composition of Oral Rehydration Solution”. Journal
of the American Medical Association 291:2628-31.
2. Gore SM, Fontaine O, Pierce NE. (1992) “Impact of rice-based
rehydration solution on stool output and duration of diarrhea;
meta-analysis of 13 clinical trials.” British Medical Journal 304: 287-91.
3. Greenough WB (2004). “The Human, Societal, and Scientific Legacy of
Cholera". Journal of Clinical Investigation 113:334-39.
4. Kelly D, Nadeau J. (2004). “Oral Rehydration Solution: A “Low-Tech”
Oft Neglected Therapy.” Nutrition Issues in Gastroenterology 21: 51-62.
5. King CK, Glass R, et al (2003). “Managing Acute Gastroenteritis Among
Children”. Morbidity and Mortality Weekly Report 52 (RR-16):1-13.
6. Rabbani GH (2000). “The Search for a Better Oral Rehydration Solution
for Cholera”. New England Journal of Medicine 342:345-47.
7. Zaman K, Yunus M, Rahman A, Chowdhury HR, Sack DA. Efficacy of a
packaged rice oral rehydration solution among children with cholera and
cholera-like illness. Acta Paediatr. 2001; 90(5):505-510. Rice-Based ORS Bibliography General ORS Bibliography
Cera Products, Inc., 55 Mathews Drive, Suite 220,
Hilton Head Island, SC 29926 US
Tel: +1 843-842-2600 or 1-888-237-2598 Fax: +1
843-842-2601 or 1-888-689-8796
updated: 21 April, 2014